Progress in novel cellular therapy options for chronic lymphocytic leukemia: the M D Anderson perspective

Clin Lymphoma Myeloma Leuk. 2014 Sep;14 Suppl(Suppl):S18-22. doi: 10.1016/j.clml.2014.06.013.

Abstract

Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made these modalities more available to a broader range of patients. Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity. This brief review discusses recent cutting-edge experience with chimeric antigen receptor T cells as well as developing cellular therapy products at the authors' institution.

Keywords: Chimeric antigen receptors; Immunotherapy; NK cells; Stem cell transplant; T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adoptive Transfer
  • Cell- and Tissue-Based Therapy / methods*
  • Humans
  • Immunotherapy / methods*
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy*
  • Receptors, Antigen, T-Cell / genetics
  • Recombinant Fusion Proteins / genetics
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism

Substances

  • Receptors, Antigen, T-Cell
  • Recombinant Fusion Proteins