Medical images are being studied to analyse the brain in neurological disorders. Measurements extracted from Diffusion tensor image (DTI) such as Fractional Anisotropy (FA) describe the brain changes caused by diseases. However, there is no single best method for the quantitative brain analysis. This paper presents a review of the existing methods and software tools for brain analysis through DTI measurements. It also states some challenges that current software tools still have to meet in order to improve automation and usability and become smarter software tools.