Metal-free three-component oxyazidation of alkenes with trimethylsilyl azide and N-hydroxyphthalimide

J Org Chem. 2015 Jan 2;80(1):290-5. doi: 10.1021/jo502327r. Epub 2014 Dec 18.

Abstract

A novel and facile oxyazidation of alkenes under metal-free and mild conditions has been reported. A remarkable feature of the developed procedure is consecutive construction of C-O and C-N bonds in one step. The process allows quick and selective assembly of alkyl azide from readily available starting materials, where N-hydroxyphthalimide was used as an oxygen-radical precursor and TMSN3 as the N3 source. A range of aromatic alkenes bearing synthetically useful functional groups was tolerated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Azides / chemical synthesis*
  • Azides / chemistry
  • Molecular Structure
  • Phthalimides / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Azides
  • Phthalimides
  • N-hydroxyphthalimide