Abstract
Clinical significance of preoperative serum NCC-ST 439 level was studied in 119 cases of colorectal cancer (90 of primary, 29 cases of recurrent). The positive rates for serum NCC-ST 439 were 28.9% in primary and 65.5% in recurrent cases. The false positive rates for benign disease were 5.6%. These rates were low when compared with those for other tumor markers. The positive rates for serum NCC-ST 439 exhibited a strong correlation with wall invasion, lymph node and liver metastases. A combination assay of NCC-ST 439, CEA and CA 19-9 produced a high positive rates as 43.3% in primary and 86.2% in recurrent cases. These results demonstrate that measurement of serum NCC-ST 439 may be useful for cancer staging and improves the diagnostic rate in combination with CEA and CA 19-9.
MeSH terms
-
Adenocarcinoma / diagnosis
-
Adenocarcinoma / pathology
-
Adenocarcinoma / secondary
-
Adenocarcinoma, Mucinous / diagnosis
-
Adenocarcinoma, Mucinous / pathology
-
Adenocarcinoma, Mucinous / secondary
-
Antigens, Tumor-Associated, Carbohydrate / analysis
-
Biomarkers, Tumor / blood*
-
Carcinoembryonic Antigen / analysis
-
Colorectal Neoplasms / diagnosis*
-
Colorectal Neoplasms / pathology
-
False Positive Reactions
-
Female
-
Humans
-
Liver Neoplasms / diagnosis
-
Liver Neoplasms / secondary
-
Lymphatic Metastasis
-
Male
-
Middle Aged
-
Neoplasm Invasiveness
-
Neoplasm Recurrence, Local / diagnosis
-
Neoplasm Recurrence, Local / pathology
-
Neoplasm Staging
-
Predictive Value of Tests
Substances
-
Antigens, Tumor-Associated, Carbohydrate
-
Biomarkers, Tumor
-
Carcinoembryonic Antigen
-
ST 439 antigen, human