Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities

Bioorg Med Chem Lett. 2015 Jan 15;25(2):259-61. doi: 10.1016/j.bmcl.2014.11.056. Epub 2014 Nov 27.

Abstract

2-(Indole-3-yl)-thiochroman-4-ones were synthesized via ionic liquid and tested for in vitro antifungal activity. The contribution of ionic liquid to Michael addition reaction is significant. Structures of all compounds are elucidated by (1)H NMR, (13)C NMR and HRMS. Most of these compounds showed better antifungal activity than fluconazole. The results suggest that 2-(indole-3-yl)-thiochroman-4-ones would be efficient antifungal agents.

Keywords: Antifungal activity; Indole; Ionic liquid; Thiochroman-4-one; Thiochromone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology*
  • Fungi / drug effects*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Ionic Liquids*
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Indoles
  • Ionic Liquids
  • indole