Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene

Adv Mater. 2015 Feb 11;27(6):1021-8. doi: 10.1002/adma.201404498. Epub 2014 Dec 15.

Abstract

A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL and DOX can be sequentially released toward the plasma membrane and nucleus, respectively.

Keywords: cytokine; drug delivery; furin; graphene oxide; nanomedicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / chemistry
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cytokines / administration & dosage
  • Cytokines / chemistry
  • Diffusion
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Furin / metabolism*
  • Graphite / chemistry*
  • Humans
  • Nanocapsules / administration & dosage
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Neoplasms, Experimental / drug therapy*
  • Neoplasms, Experimental / pathology
  • Oxides / chemistry
  • Particle Size
  • Peptides / pharmacokinetics*
  • Polyethylene Glycols / chemistry
  • TNF-Related Apoptosis-Inducing Ligand / administration & dosage
  • TNF-Related Apoptosis-Inducing Ligand / chemistry
  • Treatment Outcome

Substances

  • Cytokines
  • Nanocapsules
  • Oxides
  • Peptides
  • TNF-Related Apoptosis-Inducing Ligand
  • Polyethylene Glycols
  • Graphite
  • Doxorubicin
  • Furin