[Medullary carcinoma experience in breast oncology unit of Hospital Juarez Mexico]

Cir Cir. 2014 Jan-Feb;82(1):20-7.
[Article in Spanish]

Abstract

Background: Medullary breast cancer is a rare type, considered of good prognosis.

Objective: To know the epidemiological and clinical characteristics of the population attended in the Hospital Juarez de Mexico, to know if they are alike to described worldwide and if the treatments proposed internationally are applicable for this hospitable center.

Methods: We performed a retrospective analysis. Reviewing the records with histopathologic diagnosis of medullary breast cancer from February 1993 to February 2011. Finding 41 patients in the oncology unit of the institution.

Results: We report an incidence of 3.04%, originating in 11 Mexican States, with a low to middle socioeconomic level in 39.02%. The average age at the time of diagnosis was 50 years. No family history was reported but some patients had medical history for type 2 diabetes, hypertension and previous breast cancer. 63.41% were menopausal. The average clinical size of the tumor was 58 mm. The 63% of the cases were located in the left breast. The 53.1% were clinical stages I and II, 46.3% were clinical stages III and in 9.6% of the cases primary tumor could not be assessed. Only 47% of the patients had positive axillary lynph nodes at diagnosis. The inmunohistochemestry was only reported in 14 of the 41 patients, according to the molecular classification of breast cancer: 8 were triple negative, 2 luminal A, 1 luminal B and 3 Her2neu.

Conclusions: The Mexican population presents epidemiological and clinical characteristics similar to those patients described in other studies worldwide.

Antecedentes: el carcinoma de mama, variante medular, es poco frecuente y de buen pronóstico. Objetivo: conocer las características epidemiológicas y clínicas de la población atendida en el Hosital Juárez de México, saber si se asemejan a las descritas a nivel mundial y si los tratamientos propuestos internacionalmente son aplicables para este centro hospitalario. Material y métodos: estudio retrospectivo y descriptivo de 41 expedientes de pacientes con cáncer de mama tipo medular atendidas entre febrero de 1993 y febrero 2011. Resultados: se encontró que la incidencia de cáncer de mama de tipo medular fue de 3.04% en pacientes originarias de 11 estados mexicanos, con edad promedio de 50 años, nivel socioeconómico medio bajo para 39.02%, sin antecedentes familiares pero sí personales patológicos para: diabetes mellitus tipo 2, hipertensión arterial sistémica y cáncer de mama previo. Eran postmenopáusicas 63.41%. El promedio del tamaño clínico del tumor fue 58 mm, localizado en 63% de los casos en la mama izquierda. Los estadios clínicos fueron: 53.1% en I y II, 46.3% en III y 9.6% no etapificable. El 47% de las pacientes tenía ganglios linfáticos axilares positivos al momento del diagnóstico. La inmunohistoquímica sólo se reportó en 14 de las 41 pacientes; de acuerdo con la clasificación molecular para cáncer de mama: 8 fueron triple negativo, 2 luminal A, 1 luminal B y 3 Her2Neu. Conclusión: la población mexicana tiene características epidemiológicas y clínicas similares a las de las pacientes descritas en estudios internacionales.

Keywords: breast cancer; carcinoma; cáncer de mama; incidence; incidencia; medular; medullary.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Biomarkers, Tumor
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • Carcinoma, Medullary / chemistry
  • Carcinoma, Medullary / diagnosis
  • Carcinoma, Medullary / epidemiology*
  • Carcinoma, Medullary / pathology
  • Carcinoma, Medullary / surgery
  • Comorbidity
  • Diabetes Mellitus, Type 2 / epidemiology
  • Female
  • Humans
  • Hypertension / epidemiology
  • Incidence
  • Menopause
  • Mexico / epidemiology
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms, Second Primary / epidemiology
  • Neoplasms, Second Primary / pathology
  • Prognosis
  • Retrospective Studies
  • Socioeconomic Factors
  • Survival Rate
  • Triple Negative Breast Neoplasms / chemistry
  • Triple Negative Breast Neoplasms / epidemiology
  • Triple Negative Breast Neoplasms / pathology

Substances

  • Biomarkers, Tumor