Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE

Ho-Sung Yu; Mi-Jin Kang; Ji-Won Kwon; So-Yeon Lee; Eun Lee; Song-I Yang; Young-Ho Jung; Kyungmo Hong; Young-Joon Kim; Seung-Hwa Lee; Ha-Jung Kim; Hyung Young Kim; Ju-Hee Seo; Byoung-Ju Kim; Hyo-Bin Kim; Soo-Jong Hong

doi:10.1016/j.jaci.2014.10.040

Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE

J Allergy Clin Immunol. 2015 Mar;135(3):827-30.e5. doi: 10.1016/j.jaci.2014.10.040. Epub 2014 Dec 13.

Authors

Ho-Sung Yu¹, Mi-Jin Kang¹, Ji-Won Kwon², So-Yeon Lee³, Eun Lee⁴, Song-I Yang⁴, Young-Ho Jung⁴, Kyungmo Hong⁵, Young-Joon Kim¹, Seung-Hwa Lee¹, Ha-Jung Kim¹, Hyung Young Kim⁶, Ju-Hee Seo⁷, Byoung-Ju Kim⁸, Hyo-Bin Kim⁹, Soo-Jong Hong¹⁰

Affiliations

¹ Asan Institute for Life Science, Asan Medical Center, Seoul, Korea.
² Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea; Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
³ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
⁴ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Childhood Asthma Atopy Center, Asan Medical Center, Seoul, Korea.
⁵ Goucher College, Baltimore, Md.
⁶ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea.
⁷ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
⁸ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pediatrics, Inje University, Haeundae Paik Hospital, Gimhae, Korea.
⁹ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
¹⁰ Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Childhood Asthma Atopy Center, Asan Medical Center, Seoul, Korea. Electronic address: [email protected].

PMID: 25512082
DOI: 10.1016/j.jaci.2014.10.040

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Claudin-1 / genetics*
Claudin-1 / immunology
Dermatitis, Atopic / genetics*
Dermatitis, Atopic / immunology
Dermatitis, Atopic / microbiology
Dermatitis, Atopic / pathology
Fungi / immunology*
Genes, Reporter
Humans
Immunoglobulin E / biosynthesis*
Keratinocytes / drug effects
Keratinocytes / immunology*
Keratinocytes / microbiology
Keratinocytes / pathology
Luciferases / genetics
Luciferases / immunology
Mice
Ovalbumin / pharmacology
Patulin / pharmacology
Permeability
Polymorphism, Genetic
Primary Cell Culture
Promoter Regions, Genetic
Risk Factors
Skin / drug effects
Skin / immunology*
Skin / microbiology
Skin / pathology
Tight Junctions / drug effects
Tight Junctions / immunology
Tight Junctions / microbiology
Tight Junctions / pathology

Substances

CLDN1 protein, human
Claudin-1
Immunoglobulin E
Ovalbumin
Patulin
Luciferases