Bortezomib-induced acute pancreatitis: Case report and review of the literature

J Oncol Pharm Pract. 2016 Apr;22(2):332-4. doi: 10.1177/1078155214563813. Epub 2014 Dec 15.

Abstract

Acute pancreatitis is a rare complication of chemotherapy agents. We describe the case of a patient with multiple myeloma who developed acute pancreatitis after treatment with bortezomib, a proteasome inhibitor commonly used in the treatment of this disease. We reviewed the available medical literature on this topic, and found other seven similar cases, all after intravenous bortezomib. Our case is the first one occurring with the subcutaneous route of administration.

Keywords: Bortezomib; acute pancreatitis; proteasome inhibitors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Bortezomib / adverse effects*
  • Humans
  • Male
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / drug therapy
  • Pancreatitis / chemically induced*
  • Pancreatitis / diagnosis*
  • Proteasome Inhibitors / adverse effects*

Substances

  • Antineoplastic Agents
  • Proteasome Inhibitors
  • Bortezomib