Spiroguanidine rhodamines as fluorogenic probes for lysophosphatidic acid

Chem Commun (Camb). 2015 Jan 31;51(9):1697-700. doi: 10.1039/c4cc08818b.

Abstract

Direct determination of total lysophosphatidic acid (LPA) was accomplished using newly developed spiroguanidines derived from rhodamine B as universal fluorogenic probes. Optimum conditions for the quantitative analysis of total LPA were investigated. The linear range for the determination of total LPA is up to 5 μM with a limit of detection of 0.512 μM.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Fluorescent Dyes / chemistry*
  • Guanidines / chemistry*
  • Lysophospholipids / chemistry*
  • Molecular Structure
  • Rhodamines / chemistry*

Substances

  • Fluorescent Dyes
  • Guanidines
  • Lysophospholipids
  • Rhodamines
  • rhodamine B
  • lysophosphatidic acid