"Toll"-erance in the skin

Tina L Sumpter; Louis D Falo Jr

doi:10.1016/j.immuni.2014.11.003

"Toll"-erance in the skin

Immunity. 2014 Nov 20;41(5):677-9. doi: 10.1016/j.immuni.2014.11.003. Epub 2014 Nov 20.

Authors

Tina L Sumpter¹, Louis D Falo Jr²

Affiliations

¹ Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
² Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Pittsburgh Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: [email protected].

PMID: 25517608
DOI: 10.1016/j.immuni.2014.11.003

Abstract

Interactions between potentially pathogenic commensal bacteria and cutaneous immunity are poorly understood. In this issue of Immunity, Skabytska et al. (2014) show that S. aureus-derived TLR2/6 heterodimer ligands can recruit myeloid-derived suppressor cells into the skin, countering rather than promoting inflammation.

Publication types

Comment

MeSH terms

Animals
Humans
Myeloid Cells / immunology*
Skin / immunology*
Staphylococcal Skin Infections / immunology*
Toll-Like Receptor 2 / immunology*

Substances

Tlr2 protein, mouse
Toll-Like Receptor 2