Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration

Calliope A Dendrou; Lars Fugger

doi:10.1016/j.neuron.2014.12.012

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration

Neuron. 2014 Dec 17;84(6):1105-7. doi: 10.1016/j.neuron.2014.12.012.

Authors

Calliope A Dendrou¹, Lars Fugger²

Affiliations

¹ Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
² Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Clinical Institute, Aarhus University Hospital, Skejby Sygehus, DK-8000 Aarhus, Denmark. Electronic address: [email protected].

PMID: 25521369
DOI: 10.1016/j.neuron.2014.12.012

Abstract

In this issue, Sorbara et al. (2014) demonstrate that axonal transport impairment is an early feature of neurodegeneration in multiple sclerosis models. This transport deficit is reversible by anti-inflammatory intervention but, if untreated, can contribute to late-stage axonal dystrophy.

Publication types

Comment

MeSH terms

Animals
Axonal Transport / physiology*
Axons / physiology*
Multiple Sclerosis / pathology*
Multiple Sclerosis / physiopathology*

Grants and funding

100308/Wellcome Trust/United Kingdom