Trisomy 12 is associated with an abbreviated redistribution lymphocytosis during treatment with the BTK inhibitor ibrutinib in patients with chronic lymphocytic leukaemia

Br J Haematol. 2015 Jul;170(1):125-8. doi: 10.1111/bjh.13269. Epub 2014 Dec 18.

Authors

Philip A Thompson¹, Alessandra Ferrajoli², Susan O'Brien², William G Wierda², Michael J Keating², Jan A Burger²

Affiliations

¹ Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
² Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 25522014
DOI: 10.1111/bjh.13269

No abstract available

Keywords: chronic lymphocytic leukaemia; ibrutinib; integrins; lymphocytosis; trisomy 12.

Publication types

Letter

MeSH terms

Adenine / analogs & derivatives
Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 12 / metabolism
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Lymphocytosis / genetics*
Lymphocytosis / metabolism
Lymphocytosis / pathology
Male
Middle Aged
Piperidines
Protein Kinase Inhibitors / adverse effects
Protein Kinase Inhibitors / therapeutic use*
Pyrazoles / adverse effects
Pyrazoles / therapeutic use*
Pyrimidines / adverse effects
Pyrimidines / therapeutic use*
Trisomy / pathology*

Substances

Piperidines
Protein Kinase Inhibitors
Pyrazoles
Pyrimidines
ibrutinib
Adenine

Supplementary concepts

Chromosome 12, 12p trisomy