Abstract
MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro, indicates that they may have different functions in different types of muscle during development.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Differentiation
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Cells, Cultured
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Cloning, Molecular
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DNA / genetics
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Embryonic and Fetal Development
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Muscle Proteins / analysis
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Muscle Proteins / biosynthesis*
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Muscle Proteins / genetics
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Muscles / embryology*
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MyoD Protein*
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Myogenin
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Nuclear Proteins / analysis
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Nuclear Proteins / biosynthesis*
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Nuclear Proteins / genetics
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Organ Culture Techniques
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Organ Specificity
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Phosphoproteins / analysis
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Phosphoproteins / biosynthesis*
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Phosphoproteins / genetics
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RNA Probes
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RNA, Messenger / analysis
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Transcription, Genetic
Substances
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Muscle Proteins
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MyoD Protein
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MyoD1 myogenic differentiation protein
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Myogenin
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Nuclear Proteins
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Phosphoproteins
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RNA Probes
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RNA, Messenger
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DNA