Abstract
The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, (1)H and (13)C NMR), 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biofilms / drug effects*
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Egypt
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Iridoid Glycosides / chemistry
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Iridoid Glycosides / isolation & purification*
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Iridoid Glycosides / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification*
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Monoterpenes / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Phenylethyl Alcohol / chemistry
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Phenylethyl Alcohol / isolation & purification*
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Phenylethyl Alcohol / pharmacology*
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Staphylococcus aureus / drug effects*
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Teucrium / chemistry*
Substances
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Flavonoids
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Iridoid Glycosides
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Monoterpenes
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Phenylethyl Alcohol