Abstract
An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemistry*
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Biocompatible Materials / toxicity
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Cadmium Compounds / chemistry
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dendrimers / chemistry*
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Gold / chemistry
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Humans
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Macrophages / cytology
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Macrophages / drug effects
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Macrophages / immunology
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / toxicity
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Metal Nanoparticles / ultrastructure
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Phagocytosis / drug effects
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Polyethylene Glycols / chemistry*
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Selenium Compounds / chemistry
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Spectrometry, Fluorescence
Substances
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Biocompatible Materials
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Cadmium Compounds
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Dendrimers
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Selenium Compounds
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Polyethylene Glycols
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Gold
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cadmium selenide