Tuning nano-architectures and improving bioactivity of conducting polypyrrole coating on bone implants by incorporating bone-borne small molecules

Jingwen Liao; Ye Zhu; Zhaoyi Yin; Guoxin Tan; Chengyun Ning; Chuanbin Mao

doi:10.1039/c4tb01053a

Tuning nano-architectures and improving bioactivity of conducting polypyrrole coating on bone implants by incorporating bone-borne small molecules

J Mater Chem B. 2014;2014(2):7872-7876. doi: 10.1039/c4tb01053a.

Authors

Jingwen Liao¹, Ye Zhu², Zhaoyi Yin³, Guoxin Tan⁴, Chengyun Ning¹, Chuanbin Mao²

Affiliations

¹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
² Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman OK 73019, USA.
³ School of Materials Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
⁴ Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.

Abstract

Citric acid, a molecule present in fresh bone, was introduced into template-free electrochemical polymerization to form biocompatible coating made of polypyrrole (PPy) nano-cones on bone implants. It served not only as a dopant to tune the nano-architectures but also as a promoter to enhance bioactivity of the PPy-coated implants.

Grants and funding

R21 EB015190/EB/NIBIB NIH HHS/United States