Abstract
A digital point-of-care biosensor for measuring reactive oxygen species is presented based on novel reactive oxygen species responsive polymer-based electrodes. The biosensor is able to detect a drug-induced liver injury by monitoring the oxidative stress in the blood.
Keywords:
interdigitated microelectrodes; reactive oxygen species.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acetaminophen / adverse effects
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Animals
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Biosensing Techniques / instrumentation*
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Chemical and Drug Induced Liver Injury / blood
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Chemical and Drug Induced Liver Injury / metabolism*
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Electrodes
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Hydroxyl Radical / blood
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Mice
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Oxidative Stress* / drug effects
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Polyethylene Glycols / chemistry
Substances
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Hydroxyl Radical
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Acetaminophen
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Polyethylene Glycols