Prognostic markers of acute decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic scores

Alain Cohen-Solal; Said Laribi; Shiro Ishihara; Giuseppe Vergaro; Mathilde Baudet; Damien Logeart; Alexandre Mebazaa; Etienne Gayat; Nicolas Vodovar; Domingo A Pascual-Figal; Marie-France Seronde

doi:10.1016/j.acvd.2014.10.002

Prognostic markers of acute decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic scores

Arch Cardiovasc Dis. 2015 Jan;108(1):64-74. doi: 10.1016/j.acvd.2014.10.002. Epub 2014 Nov 4.

Authors

Affiliations

¹ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France. Electronic address: [email protected].
² UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Emergency department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, Paris, France.
³ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Cardiology department, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
⁴ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Cardiology and cardiovascular medicine division, Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica, CNR-Regione Toscana, Pisa, Italy.
⁵ Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France.
⁶ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France.
⁷ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France; Anaesthesia-ICU department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, Paris, France.
⁸ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France.
⁹ Cardiology department, hospital Virgen de la Arrixaca, school of medicine, university of Murcia, Murcia, Spain.
¹⁰ UMR-S 942 "Biomarqueurs et Insuffisances Cardiaques", Paris, France; Cardiology department, CHU de Besançon, Besançon, France.

PMID: 25534886
DOI: 10.1016/j.acvd.2014.10.002

Abstract

Rapidly assessing outcome in patients with acute decompensated heart failure is important but prognostic factors may differ from those used routinely for stable chronic heart failure. Multiple plasma biomarkers, besides the classic natriuretic peptides, have recently emerged as potential prognosticators. Furthermore, prognostic scores that combine clinical and biochemical data may also be useful. However, compared with the scores used in chronic heart failure, scores for acute decompensated heart failure have not been validated. This article reviews potential biomarkers, with a special focus on biochemical biomarkers, and possible prognostic scores that could be used by the clinician when assessing outcome in patients with acute heart failure.

Keywords: Acute decompensated heart failure; Biomarkers; Biomarqueurs; Insuffisance cardiaque aiguë; Natriuretic peptides; Peptides natriurétiques; Prognosis; Pronostic; Scores; Scores de risque.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acute Disease
Biomarkers / blood*
Decision Support Techniques*
Heart Failure / blood
Heart Failure / diagnosis*
Heart Failure / physiopathology
Heart Failure / therapy
Humans
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Time Factors

Substances

Biomarkers