1 Department of Genomic Medicine, Manchester Academic Health Science Centre, University of Manchester, St Mary's Hospital, Manchester, England (D.G.R.E.); Academic Unit of Paediatric Radiology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre; Centre for Imaging Sciences, Institute of Population Health, University of Manchester, Stopford Building; Children's Brain Tumour Research Network, University of Manchester, Royal Manchester Children's Hospital, Oxford Road, Manchester, United Kingdom (S.M.S.).