Bioinspired formation of 3D hierarchical CoFe2O4 porous microspheres for magnetic-controlled drug release

ACS Appl Mater Interfaces. 2015 Jan 21;7(2):1327-33. doi: 10.1021/am507689a. Epub 2015 Jan 8.

Abstract

Bioinspired by the morphology of dandelion pollen grains, we successfully prepared a template-free solution-based method for the large-scale preparation of three-dimensional (3D) hierarchical CoFe2O4 porous microspheres. Besides, on the basis of the effect of the reaction time on the morphology evolution of the precursor, we proposed an in situ dissolution-recrystallization growth mechanism with morphology and phase change to understand the formation of dandelion pollenlike microspheres. Doxorubicin hydrochloride, an anticancer drug, is efficiently loaded into the CoFe2O4 microspheres. The magnetic nanoparticles as field-controlled drug carriers offer a unique power of magnetic guidance and field-triggered drug-release behavior. Therefore, 3D hierarchical CoFe2O4 porous microspheres demonstrate the great potential for drug encapsulation and controlled drug-release applications.

Keywords: CoFe2O4; bioinspired; controlled release; microsphere.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Delayed-Action Preparations / chemistry*
  • Drug Carriers / chemistry*
  • Drug Delivery Systems / instrumentation*
  • Drug Liberation
  • Magnetite Nanoparticles / chemistry*
  • Microspheres
  • Pollen / chemistry
  • Polymers / chemical synthesis
  • Polymers / chemistry
  • Porosity

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • Magnetite Nanoparticles
  • Polymers