Relevance of age at diagnosis to prevention of late-onset group B streptococcal disease by maternal immunization

Morven S Edwards; Marcia A Rench; Carol J Baker

doi:10.1097/INF.0000000000000640

Relevance of age at diagnosis to prevention of late-onset group B streptococcal disease by maternal immunization

Pediatr Infect Dis J. 2015 May;34(5):538-9. doi: 10.1097/INF.0000000000000640.

Authors

Morven S Edwards¹, Marcia A Rench, Carol J Baker

Affiliation

¹ From the *Section of Infectious Disease, Department of Pediatrics, and †Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas; and ‡Center for Vaccine Awareness and Research, Texas Children's Hospital, Houston, Texas.

PMID: 25545183
DOI: 10.1097/INF.0000000000000640

Abstract

Among 248 infants with late-onset group B streptococcal (GBS) disease from 1993 to 2012, approximately two thirds (63%) had a gestation of at least 35 weeks and 72% of these became ill within 6 weeks of life (median 27 days), suggesting that third trimester maternal GBS immunization could substantially reduce the late-onset GBS disease burden in the United States.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases* / diagnosis
Infant, Newborn, Diseases* / epidemiology
Infant, Newborn, Diseases* / microbiology
Infectious Disease Transmission, Vertical
Pregnancy
Pregnancy Complications, Infectious
Streptococcal Infections* / diagnosis
Streptococcal Infections* / epidemiology
Streptococcal Infections* / microbiology
Streptococcal Infections* / transmission
Streptococcus agalactiae*
Texas / epidemiology