Expiration-phase template-based motion correction of free-breathing abdominal dynamic contrast enhanced MRI

IEEE Trans Biomed Eng. 2015 Apr;62(4):1215-1225. doi: 10.1109/TBME.2014.2385307. Epub 2014 Dec 23.

Abstract

This paper studies a novel method to compensate for respiratory and peristaltic motions in abdominal dynamic contrast enhanced magnetic resonance imaging. The method consists of two steps: 1) expiration-phase "template" construction and retrospective gating of the data to the template; and 2) nonrigid registration of the gated volumes. Landmarks annotated by three experts were used to directly assess the registration performance. A tri-exponential function fit to time intensity curves from regions of interest was used to indirectly assess the performance. One of the parameters of the tri-exponential fit was used to quantify the contrast enhancement. Our method achieved a mean target registration error (MTRE) of 2.12, 2.27, and 2.33 mm with respect to annotations by expert, which was close to the average interobserver variability (2.07 mm). A state-of-the-art registration method achieved an MTRE of 2.83-3.10 mm. The correlation coefficient of the contrast enhancement parameter to the Crohn's disease endoscopic index of Severity (r = 0.60, p = 0.004) was higher than the correlation coefficient for the relative contrast enhancement measurements values of two observers ( r(Observer 1) = 0.29, p = 0.2; r(Observer 2) = 0.45, p = 0.04). Direct and indirect assessments show that the expiration-based gating and a nonrigid registration approach effectively corrects for respiratory motion and peristalsis. The method facilitates improved enhancement measurement in the bowel wall in patients with Crohn's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / physiology
  • Contrast Media
  • Crohn Disease / pathology
  • Crohn Disease / physiopathology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Peristalsis / physiology*
  • Respiratory Mechanics / physiology*

Substances

  • Contrast Media