In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer

Aravind Kumar Rengan; Amirali B Bukhari; Arpan Pradhan; Renu Malhotra; Rinti Banerjee; Rohit Srivastava; Abhijit De

doi:10.1021/nl5045378

In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer

Nano Lett. 2015 Feb 11;15(2):842-8. doi: 10.1021/nl5045378. Epub 2015 Jan 7.

Authors

Aravind Kumar Rengan¹, Amirali B Bukhari, Arpan Pradhan, Renu Malhotra, Rinti Banerjee, Rohit Srivastava, Abhijit De

Affiliation

¹ Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay , Mumbai, India.

PMID: 25554860
DOI: 10.1021/nl5045378

Abstract

We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs) capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of LiposAu NPs performed in a small animal model indicates in situ degradation in hepatocytes and further getting cleared through the hepato-biliary and renal route. Further, the therapeutic potential of LiposAu NPs tested in mouse tumor xenograft model using NIR laser (750 nm) illumination resulted in complete ablation of the tumor mass, thus prolonging disease-free survival.

Keywords: Gold nanoparticles; cancer nanotechnology; liposomes; photothermal therapy; theranostics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials*
Cell Line, Tumor
Combined Modality Therapy
Disease Models, Animal
Gold / chemistry*
Hyperthermia, Induced*
Liposomes*
Metal Nanoparticles / chemistry
Metal Nanoparticles / therapeutic use*
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms / therapy*
Phototherapy*
Xenograft Model Antitumor Assays

Substances

Biocompatible Materials
Liposomes
Gold