2',3'-cyclic nucleotide-3'-phosphodiesterase activity as an index of myelin in the post-mortem brains of patients with Alzheimer's disease

K J Reinikainen; A Pitkänen; P J Riekkinen

doi:10.1016/0304-3940(89)90230-9

2',3'-cyclic nucleotide-3'-phosphodiesterase activity as an index of myelin in the post-mortem brains of patients with Alzheimer's disease

Neurosci Lett. 1989 Nov 20;106(1-2):229-32. doi: 10.1016/0304-3940(89)90230-9.

Authors

K J Reinikainen¹, A Pitkänen, P J Riekkinen

Affiliation

¹ Department of Neurology, University of Kuopio, Finland.

PMID: 2555748
DOI: 10.1016/0304-3940(89)90230-9

Abstract

The activity of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) was determined as an index of myelin in the post-mortem brain samples of 16 patients with Alzheimer's disease (AD) and of 14 controls. The CNPase activity was mildly increased in the temporal, hippocampal and parietal cortex in AD subjects pointing to a relative sparing of myelin as compared to the neuron loss within cortex in AD. In the hippocampus the CNPase activity was decreased in AD patients indicating loss of myelin and thus myelinated axons in this area in AD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2',3'-Cyclic-Nucleotide Phosphodiesterases / metabolism*
Aged
Aged, 80 and over
Alzheimer Disease / enzymology*
Brain / enzymology*
Brain / pathology
Female
Hippocampus / enzymology
Hippocampus / pathology
Humans
Male
Myelin Sheath / metabolism*

Substances

2',3'-Cyclic-Nucleotide Phosphodiesterases