The DISCUSS Project: Revised Points to Consider for the Derivation of Induced Pluripotent Stem Cell Lines From Previously Collected Research Specimens

Geoffrey P Lomax; Sara Chandros Hull; Rosario Isasi

doi:10.5966/sctm.2014-0192

The DISCUSS Project: Revised Points to Consider for the Derivation of Induced Pluripotent Stem Cell Lines From Previously Collected Research Specimens

Stem Cells Transl Med. 2015 Feb;4(2):123-9. doi: 10.5966/sctm.2014-0192. Epub 2015 Jan 5.

Authors

Geoffrey P Lomax¹, Sara Chandros Hull², Rosario Isasi³

Affiliations

¹ California Institute for Regenerative Medicine, San Francisco, California, USA; [email protected] [email protected].
² Office of the Clinical Director, National Human Genome Research Institute and Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA;
³ Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

Abstract

Human somatic cell reprogramming is a leading technology for accelerating disease modeling and drug discovery. The Deriving Induced Stem Cells Using Stored Specimens (DISCUSS) project is a consensus-building initiative designed to consider how human somatic cells obtained under general biomedical research protocols can be used in induced pluripotent stem cell (iPSC) derivation. We previously published a draft list of points to consider for the use of previously collected specimens in iPSC research and then initiated a structured feedback and comment process. Here, we present a summary of this feedback and revised list of points to consider.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Line
Drug Discovery*
Humans
Induced Pluripotent Stem Cells*
Specimen Handling*
Stem Cell Research