Abstract
The clinical and neurophysiological features of 23 patients affected by essential cryoglobulinemia (EC) have been studied. It was possible to perform sural nerve biopsy in 3 cases. Six patients were found to be affected by a peripheral neuropathy, according to the WHO criteria, while in 8 other patients clinical and neurophysiological signs of a milder peripheral nervous system (PNS) involvement were evident. The incidence of PNS involvement seems to be high (60.9%). Neurophysiological and histological studies were indicative of a mainly axonal damage.
MeSH terms
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Action Potentials / physiology
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Adult
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Aged
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Biopsy, Needle
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Cryoglobulinemia / complications*
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Demyelinating Diseases / complications
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Demyelinating Diseases / pathology
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Demyelinating Diseases / physiopathology
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Electromyography
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Female
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Humans
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Kidney Diseases / complications*
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Male
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Middle Aged
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Paresthesia / complications
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Paresthesia / pathology
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Paresthesia / physiopathology
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Peripheral Nervous System Diseases / complications*
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Peripheral Nervous System Diseases / pathology
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Peripheral Nervous System Diseases / physiopathology
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Reflex, Abnormal / physiology
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Reflex, Stretch / physiology
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Sural Nerve / pathology
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Sural Nerve / physiopathology