Buruli ulcer in South Western Nigeria: a retrospective cohort study of patients treated in Benin

Estelle Marion; Kevin Carolan; Ambroise Adeye; Marie Kempf; Annick Chauty; Laurent Marsollier

doi:10.1371/journal.pntd.0003443

Buruli ulcer in South Western Nigeria: a retrospective cohort study of patients treated in Benin

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3443. doi: 10.1371/journal.pntd.0003443. eCollection 2015 Jan.

Authors

Estelle Marion¹, Kevin Carolan², Ambroise Adeye³, Marie Kempf⁴, Annick Chauty³, Laurent Marsollier⁵

Affiliations

¹ Centre de Diagnostic et de Traitement de l'Ulcère de Buruli de Pobè, Fondation Raoul Follereau, Pobè, Bénin; ATOMycA, Inserm Atip-Avenir Team, CRCNA, Inserm U892, 6299 CNRS, University and Centre Hospitalier Universitaire d'Angers, Angers, France.
² UMR Mivegec, IRD-CNRS-Universities of Montpellier I and II, Montpellier, Centre IRD de Montpellier, Montpellier, France.
³ Centre de Diagnostic et de Traitement de l'Ulcère de Buruli de Pobè, Fondation Raoul Follereau, Pobè, Bénin.
⁴ Laboratoire de bactériologie et d'hygiène hospitalière, Centre Hospitalier Universitaire d'Angers, Angers, France.
⁵ ATOMycA, Inserm Atip-Avenir Team, CRCNA, Inserm U892, 6299 CNRS, University and Centre Hospitalier Universitaire d'Angers, Angers, France.

Abstract

Nigeria is known to be endemic to Buruli ulcer, but epidemiological data are remarkably rare. Here, we present a large cohort of 127 PCR-confirmed M. ulcerans infection patients coming from Nigeria and treated in a neighbouring country, Benin. Severe lesions and delay of consultation are factors that should encourage establishment of a treatment centre in South Western Nigeria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Benin / epidemiology
Buruli Ulcer / epidemiology*
Child
Female
Humans
Male
Nigeria / epidemiology
Retrospective Studies
Young Adult

Grants and funding

This study was supported by the Fondation Raoul Follereau, the Institut National de la Santé et de la Recherche Médicale (Inserm, Programme Inserm Avenir) and by the Agence Nationale de Recherche sur le SIDA et les Hépatites. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.