Abstract
Two new anthraquinones, melrubiellin C (1) and melrubiellin D (2), were isolated from the aerial parts of Melandrium firmum Rohrbach, together with eight known compounds (3-10). The structures of these compounds were elucidated using 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. All isolated compounds were tested for their cytotoxicity against NCI-H460, Hep G2, MKN-28 and A-549 cells. Of these 10 compounds, 1 and 2 exhibited moderate cytotoxicity with IC50 values ranging from 9.54 to 32.41 μM.
Keywords:
Anthraquinone dimmer; Caryophyllaceae; Cytotoxicity; Melandrium firmum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Caryophyllaceae / chemistry*
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Cell Line, Tumor
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Plant Components, Aerial
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
Substances
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Plant Extracts