Do Statins Reduce the Health and Health Care Costs of Obesity?

Pharmacoeconomics. 2015 Jul;33(7):723-34. doi: 10.1007/s40273-014-0234-y.

Abstract

Context: Obesity impacts both individual health and, given its high prevalence, total health care spending. However, as medical technology evolves, health outcomes for a number of obesity-related illnesses improve. This article examines whether medical innovation can mitigate the adverse health and spending associated with obesity, using statins as a case study. Because of the relationship between obesity and hypercholesterolaemia, statins play an important role in the medical management of obese individuals and the prevention of costly obesity-related sequelae.

Methods: Using well-recognized estimates of the health impact of statins and the Future Elderly Model (FEM)-an established dynamic microsimulation model of the health of Americans aged over 50 years-we estimate the changes in life expectancy, functional status and health care costs of obesity due to the introduction and widespread use of statins.

Results: Life expectancy gains of statins are estimated to be 5-6 % greater for obese individuals than for healthy-weight individuals, but most of these additional gains are associated with some level of disability. Considering both medical spending and the value of quality-adjusted life-years, statins do not significantly alter the costs of class 1 and 2 obesity (body mass index [BMI] ≥30 and ≥35 kg/m(2), respectively) and they increase the costs of class 3 obesity (BMI ≥40 kg/m(2)) by 1.2 %.

Conclusions: Although statins are very effective medications for lowering the risk of obesity-associated illnesses, they do not significantly reduce the costs of obesity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Computer Simulation
  • Cost-Benefit Analysis
  • Health Care Costs / statistics & numerical data
  • Health Care Costs / trends*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / economics*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Life Expectancy
  • Markov Chains
  • Models, Economic*
  • Obesity / drug therapy
  • Obesity / economics*
  • Quality-Adjusted Life Years

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors