Are QTc interval changes after meal intake a reasonable method to prove assay sensitivity in thorough QT studies?

J Electrocardiol. 2015 Mar-Apr;48(2):276-7. doi: 10.1016/j.jelectrocard.2015.01.005. Epub 2015 Jan 6.

Authors

Katerina Hnatkova¹, Donna Kowalski², James J Keirns², E Marcel van Gelderen³, Marek Malik⁴

Affiliations

¹ Imperial College, London, England.
² Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA.
³ Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Europe B.V., Leiden, The Netherlands.
⁴ St. Paul's Cardiac Electrophysiology and Imperial College, London, England. Electronic address: [email protected].

PMID: 25578392
DOI: 10.1016/j.jelectrocard.2015.01.005

No abstract available

Publication types

Letter
Comment

MeSH terms

Eating / physiology*
Electrocardiography, Ambulatory / methods*
Female
Heart Rate / physiology*
Humans
Male
Postprandial Period / physiology*

Grants and funding

PG/12/77/29857/BHF_/British Heart Foundation/United Kingdom