Abstract
Two new (1 and 2) and seven known phenolic compounds were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their structures were identified by spectroscopic analysis and comparing with reported values. The inhibitory effects of each compound on soluble epoxide hydrolase (sEH) were evaluated. Among them, compounds 2, 6, and 9 potently inhibited sEH activity.
Keywords:
Gentiana scabra; Gentianaceae; phenolic compound; soluble epoxide hydrolase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Epoxide Hydrolases / antagonists & inhibitors*
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Epoxide Hydrolases / chemistry*
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Gentiana / chemistry*
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Methanol / chemistry
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Phenols / chemistry
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Phenols / isolation & purification
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Phenols / pharmacology*
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Rhizome / chemistry*
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Solubility
Substances
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Enzyme Inhibitors
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Phenols
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Epoxide Hydrolases
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Methanol