Catalysts for RNA and DNA modification

Dennis Gillingham; Ramla Shahid

doi:10.1016/j.cbpa.2014.12.025

Catalysts for RNA and DNA modification

Curr Opin Chem Biol. 2015 Apr:25:110-4. doi: 10.1016/j.cbpa.2014.12.025. Epub 2015 Jan 12.

Authors

Dennis Gillingham¹, Ramla Shahid²

Affiliations

¹ St. Johanns-Ring 19, Basel 4056, Switzerland. Electronic address: [email protected].
² COMSATS Institute of Technology, Park Road, Islamabad, Pakistan.

PMID: 25590584
DOI: 10.1016/j.cbpa.2014.12.025

Abstract

To study DNAs and RNAs it is often necessary to chemically modify them. Nature's strategy for nucleic acid modification is to use selective catalysts, and chemists have begun to emulate this conceptual approach. In this review we present a summary of catalytic approaches toward the construction of modified RNAs and DNAs and outline our opinions on where new research is needed.

Publication types

Review

MeSH terms

Catalysis
DNA / chemistry
DNA / metabolism*
DNA, Catalytic / metabolism
Humans
Organometallic Compounds / chemistry
RNA / chemistry
RNA / metabolism*
RNA, Catalytic / metabolism

Substances

DNA, Catalytic
Organometallic Compounds
RNA, Catalytic
RNA
DNA