Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

Gregory R Naumiec; Grace Lincourt; Jeremy P Clever; Michael A McGregor; Abraham Kovoor; Brenton DeBoef

doi:10.1039/c4ob02165g

Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

Org Biomol Chem. 2015 Mar 7;13(9):2537-40. doi: 10.1039/c4ob02165g.

Authors

Gregory R Naumiec¹, Grace Lincourt, Jeremy P Clever, Michael A McGregor, Abraham Kovoor, Brenton DeBoef

Affiliation

¹ Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, Rhode Island 02881, USA. [email protected].

PMID: 25592739
DOI: 10.1039/c4ob02165g

Abstract

The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (K(d) = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Carbolines / chemistry*
Dopamine Plasma Membrane Transport Proteins / chemistry*
HEK293 Cells
Humans
Lanthanoid Series Elements / chemistry*
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*

Substances

Carbolines
Dopamine Plasma Membrane Transport Proteins
Lanthanoid Series Elements
Organometallic Compounds
tert-butyl beta-carboline-3-carboxylate