Abstract
A novel fluorescence probe (HB) has been designed and synthesized to image selenol in living cells and in vivo for the first time, and used to investigate the Na2SeO3 anticancer mechanism in HepG2 cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Apoptosis
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Fluorescent Dyes / pharmacology*
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Hep G2 Cells
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Humans
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Indoles / pharmacology*
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Optical Imaging
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Organoselenium Compounds / pharmacology*
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Selenium Compounds / metabolism*
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Sodium Selenite / pharmacology*
Substances
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2-(4-(2-(benzoselenadiazol-5-yl)vinyl)styryl)-1-ethyl-3,3-dimethylindolium
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Antineoplastic Agents
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Fluorescent Dyes
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Indoles
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Organoselenium Compounds
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Selenium Compounds
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selenol
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Sodium Selenite