Aptamer-mediated up-conversion core/MOF shell nanocomposites for targeted drug delivery and cell imaging

Sci Rep. 2015 Jan 19:5:7851. doi: 10.1038/srep07851.

Abstract

Multifunctional nanocarriers for targeted bioimaging and drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb(3+)/Er(3+) nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for drug storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Aptamers, Nucleotide / chemistry*
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers / chemistry*
  • Flow Cytometry
  • HEK293 Cells
  • Humans
  • Lasers
  • Luminescent Measurements
  • MCF-7 Cells
  • Microscopy, Confocal
  • Nanocomposites / chemistry*
  • Organometallic Compounds / chemistry*

Substances

  • Antibiotics, Antineoplastic
  • Aptamers, Nucleotide
  • Drug Carriers
  • Organometallic Compounds
  • Doxorubicin