Abstract
The enzymatic activities of Na+/K+ ATPase and Ca2+ ATPase were determined on erythrocyte membranes from 9 normotensive and 9 gestational hypertensive pregnant women near term. A reduction in the activity of the Na+/K+ ATPase and a relative increase in the activity of the Ca2+ ATPase were found in the hypertensive patients, possibly due to a conformational alteration of erythrocyte membranes. This observation supports the possible role of the transmembrane cation transport in the pathogenesis of gestational hypertension.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biological Transport
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Calcium / metabolism*
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Calcium-Transporting ATPases / metabolism*
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Female
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Humans
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Hypertension / enzymology
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Hypertension / metabolism*
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Kinetics
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Pregnancy
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Pregnancy Complications, Cardiovascular / enzymology
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Pregnancy Complications, Cardiovascular / metabolism*
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Proteinuria / metabolism
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Sodium / metabolism*
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Sodium-Potassium-Exchanging ATPase / metabolism
Substances
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Sodium
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Calcium-Transporting ATPases
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Sodium-Potassium-Exchanging ATPase
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Calcium