Objective: To clarify the association of rs11196218 polymorphism in transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Asian population by a case-control study and meta-analysis.
Methods: In the case-control study, 1842 patients with T2DM and 7777 normal glucose-tolerant controls in the Henan province of China were genotyped for rs11196218 in TCF7L2 by PCR-ligase detection reaction. We used allele, co-dominant, dominant and recessive models to evaluate the risk association and performed a meta-analysis of the results of different genetic models in previous studies and the current study.
Results: The AG genotype of rs11196218 was associated with risk of T2DM in the Henan population (odds ratio 1.37, 95% confidence interval 1.06-1.78), and dominant model showed marginal significant association (1.28, 0.99-1.67). Meta-analysis of 10 studies revealed the dominant model associated with T2DM in the overall population (1.20, 1.05-1.36). When stratified by region (southern and northern China and Japan), both the AG genotype and the dominant model were associated with risk of T2DM in southern Chinese (1.31, 1.03-1.66; 1.27, 1.01-1.60, respectively).
Conclusion: The rs11196218 polymorphism in TCF7L2 is associated with risk of T2DM in Asian population.
Keywords: 95% CI, 95% confidence interval; MAF, minor allele frequency; OR, odds ratio; PARP, population-attributable risk proportion; PCR–LDR, polymerase chain reaction–ligase detection reaction; SNP, single nucleotide polymorphism; Single nucleotide polymorphism; T2DM, type 2 diabetes mellitus; TCF7L2; TCF7L2, factor 7-like 2 gene; Type 2 diabetes mellitus; rs11196218.