Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen

Timothy J Thauland; Manish J Butte

doi:10.1016/j.immuni.2014.12.026

Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen

Immunity. 2015 Jan 20;42(1):6-8. doi: 10.1016/j.immuni.2014.12.026.

Authors

Timothy J Thauland¹, Manish J Butte²

Affiliations

¹ Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
² Department of Pediatrics, Stanford University, Stanford, CA 94305, USA. Electronic address: [email protected].

PMID: 25607451
DOI: 10.1016/j.immuni.2014.12.026

Abstract

Notch receptors are widely expressed and have recognized functions in thymocytes and mature T cells. In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.

Publication types

Comment

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
Carcinoma / immunology*
Female
Male
Receptor Cross-Talk*
Receptors, Notch / metabolism*
Signal Transduction*

Substances

Receptors, Notch