Abstract
The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype convertibility is adopted to establish for the first time the simultaneous mutasynthesis of both types of C17-benzene ansamycins (C17BAs). Three of the newly generated unnatural compounds showed potent cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Lactams, Macrocyclic / chemistry
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MCF-7 Cells
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Molecular Structure
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Rifabutin / analogs & derivatives*
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Rifabutin / chemical synthesis*
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Rifabutin / chemistry
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Rifabutin / pharmacology
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Streptomyces / chemistry*
Substances
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Antineoplastic Agents
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Lactams, Macrocyclic
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Rifabutin