Subclonality and prenatal origin of RAS mutations in KMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia

Br J Haematol. 2015 Jul;170(2):268-71. doi: 10.1111/bjh.13279. Epub 2015 Jan 22.

Authors

Mariana Emerenciano¹, Thayana da C Barbosa¹, Bruno de Almeida Lopes¹, Claus Meyer², Rolf Marschalek², Maria S Pombo-de-Oliveira³

Affiliations

¹ Paediatric Haematology-Oncology Programme, Research Centre, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
² Institute of Pharmaceutical Biology/ZAFES/Diagnostic Centre of Acute Leukaemia (DCAL), Goethe-University of Frankfurt, Frankfurt/Main, Germany.
³ Paediatric Haematology-Oncology Programme, Research Centre, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. [email protected].

PMID: 25613690
DOI: 10.1111/bjh.13279

No abstract available

Keywords: KMT2A (MLL); RAS; infant ALL; pyrosequencing.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Genes, ras*
Histone-Lysine N-Methyltransferase / genetics*
Humans
Infant
Mutation*
Myeloid-Lymphoid Leukemia Protein / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Translocation, Genetic*

Substances

KMT2A protein, human
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase