Are CXCL13/CXCR5/FAK critical regulators of MSCs migration and differentiation?

Yan Zhang; Chunhui Ma; Yinxian Yu; Man Liu; Chengqing Yi

doi:10.1016/j.mehy.2014.12.025

Are CXCL13/CXCR5/FAK critical regulators of MSCs migration and differentiation?

Med Hypotheses. 2015 Mar;84(3):213-5. doi: 10.1016/j.mehy.2014.12.025. Epub 2015 Jan 9.

Authors

Yan Zhang¹, Chunhui Ma², Yinxian Yu³, Man Liu⁴, Chengqing Yi⁵

Affiliations

¹ Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. Electronic address: [email protected].
² Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: [email protected].
³ Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: [email protected].
⁴ Institute of Food and Nutraceutical Science, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: [email protected].
⁵ Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: [email protected].

PMID: 25617044
DOI: 10.1016/j.mehy.2014.12.025

Abstract

Osteonecrosis of the femoral head is a common and challenging disease worldwide. The traditional treatments, such as core decompression procedure and joint replacement, are not satisfactory due to the limited outcome, repetitive surgery and cost. In recent years, autologous mesenchymal stem cells (MSCs) implantation into the femoral head has emerged as a promising method. The homing and differentiation of MSCs is determined by chemokines and their receptors, specific signals present in the micro-environment of the damaged tissue. CXCL13/CXCR5, highly expressed in the osteoblast and MSCs, are tissue specific and selectively migrate MSCs, thereafter triggering phosphorylation of focal adhesionkinase through mitogen-activated protein kinase pathway. Considering these characteristics, we hypothesize that CXCL13/CXCR5/FAK are critical signals in the trafficking and differentiation of MSCs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation / physiology
Cell Movement / physiology
Chemokine CXCL13 / metabolism*
Femur Head / cytology*
Femur Head / pathology
Focal Adhesion Kinase 1 / metabolism*
Humans
Mesenchymal Stem Cell Transplantation / methods*
Mesenchymal Stem Cells / metabolism
Mesenchymal Stem Cells / physiology*
Models, Biological*
Osteonecrosis / therapy*
Receptors, CXCR5 / metabolism*

Substances

CXCR5 protein, human
Chemokine CXCL13
Receptors, CXCR5
Focal Adhesion Kinase 1
PTK2 protein, human