Abstract
The time course of recovery of beta-adrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of beta-adrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: beta-adrenoceptors recovered faster than VIP/helodermin receptors.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenylyl Cyclases / metabolism
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Animals
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Cell Line, Transformed
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Cell Transformation, Viral
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Down-Regulation / physiology*
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Intercellular Signaling Peptides and Proteins
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Isoproterenol / pharmacology
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Lymphoma
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Mice
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Peptides / pharmacology
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Receptors, Adrenergic, beta / physiology*
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Receptors, Gastrointestinal Hormone / physiology*
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Receptors, Vasoactive Intestinal Peptide
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T-Lymphocytes / metabolism*
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Vasoactive Intestinal Peptide*
Substances
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Intercellular Signaling Peptides and Proteins
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Peptides
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Receptors, Adrenergic, beta
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Receptors, Gastrointestinal Hormone
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Receptors, Vasoactive Intestinal Peptide
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Vasoactive Intestinal Peptide
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heliodermin
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Adenylyl Cyclases
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Isoproterenol