Studies of terminal differentiation of electrolyte transport in the renal proximal tubule using short-term primary cultures

S H Larsson; L Larsson; C Lechene; A Aperia

doi:10.1007/BF00858547

Studies of terminal differentiation of electrolyte transport in the renal proximal tubule using short-term primary cultures

Pediatr Nephrol. 1989 Jul;3(3):363-8. doi: 10.1007/BF00858547.

Authors

S H Larsson¹, L Larsson, C Lechene, A Aperia

Affiliation

¹ Department of Paediatrics, St. Göran's Children's Hospital, Stockholm, Sweden.

PMID: 2562016
DOI: 10.1007/BF00858547

Abstract

There are several lines of indirect evidence suggesting that the renal tubule cells have not yet reached terminal differentiation at birth. Methods used in cell biology can now be applied to study renal ontogeny. This review describes how primary cultures of proximal tubule cells from rats can be used to investigate developmental changes in Na permeability and Na-K-ATPase-mediated transport.

Publication types

Review

MeSH terms

Animals
Biological Transport, Active
Cell Differentiation
Cells, Cultured
Kidney Tubules, Proximal / cytology*
Kidney Tubules, Proximal / metabolism
Potassium / pharmacokinetics*
Rats
Sodium / pharmacokinetics*
Sodium-Potassium-Exchanging ATPase / metabolism*

Substances

Sodium
Sodium-Potassium-Exchanging ATPase
Potassium