[Biological activity of gamma interferon on various cell types in human and murine systems]

M Zucca; M Fiscella; G Gribaudo; T Musso; G Cavallo; S Landolfo

[Biological activity of gamma interferon on various cell types in human and murine systems]

G Batteriol Virol Immunol. 1989 Jan-Dec;82(1-12):82-7.

[Article in Italian]

Authors

M Zucca¹, M Fiscella, G Gribaudo, T Musso, G Cavallo, S Landolfo

Affiliation

¹ Istituto di Microbiologia dell'Università di Torino.

PMID: 2562300

Abstract

The effects of interferon (IFN gamma) and of IFN alpha/beta on normal T and B lymphocytes and various T and non-T human and murine cell lines have been investigated. IFN gamma, unlike IFN alpha/beta, did not promote the antiviral state in T cells. The lack of antiviral activity was confirmed at the biochemical level by the finding that 2',5' oligoadenylate synthetase activity is not induced in T cells by IFN gamma only.

Publication types

Comparative Study

MeSH terms

2',5'-Oligoadenylate Synthetase / metabolism
Amniotic Fluid / cytology
Animals
Cells, Cultured
Fibroblasts / drug effects
Humans
Interferon Type I / pharmacology
Interferon-gamma / pharmacology*
Macrophages / drug effects
Mice
Species Specificity
T-Lymphocytes / drug effects*
T-Lymphocytes / enzymology
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / enzymology
Vesicular stomatitis Indiana virus / physiology

Substances

Interferon Type I
Interferon-gamma
2',5'-Oligoadenylate Synthetase