Abstract
Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd2(dba)3 with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 °C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkylation
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Carbon / chemistry
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Catalysis
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Ligands
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Magnetic Resonance Spectroscopy
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Metals / chemistry
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Palladium / chemistry*
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Phenols / chemistry*
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Solvents / chemistry
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Stereoisomerism
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Substrate Specificity
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Temperature
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Tetrahydroisoquinolines / chemistry*
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Time Factors
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Toluene / chemistry
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Transition Elements / chemistry
Substances
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Alkaloids
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Ligands
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Metals
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Phenols
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Solvents
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Tetrahydroisoquinolines
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Transition Elements
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Toluene
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Palladium
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Carbon