Abstract
We report the discovery, synthesis, and application of a new class of non-C2-symmetric phosphoramidite ligands derived from pyroglutamic acid for use in both oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketones. The resulting chiral products are typically obtained in high yield with good to excellent levels of enantioselectivity.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Alkylation
-
Allyl Compounds / chemistry*
-
Catalysis
-
Ketones / chemistry*
-
Ligands
-
Organophosphorus Compounds / chemistry
-
Oxidation-Reduction
-
Palladium / chemistry*
-
Stereoisomerism
Substances
-
Allyl Compounds
-
Ketones
-
Ligands
-
Organophosphorus Compounds
-
phosphoramidite
-
Palladium