Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population

M Vidaud; A Kitzis; C Ferec; D Bozon; V Dumur; G Giraud; F David; O Pascal; M Auvinet; Y Morel

doi:10.1007/BF00293899

Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population

Hum Genet. 1989 Jan;81(2):183-4. doi: 10.1007/BF00293899.

Authors

M Vidaud¹, A Kitzis, C Ferec, D Bozon, V Dumur, G Giraud, F David, O Pascal, M Auvinet, Y Morel, et al.

Affiliation

¹ INSERM U. 91, Hôpital H. Mondor, Créteil, France.

PMID: 2563252
DOI: 10.1007/BF00293899

Abstract

In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cystic Fibrosis / genetics*
France
Genetic Linkage*
Genetic Markers*
Haplotypes*
Humans
Polymorphism, Restriction Fragment Length

Substances

Genetic Markers