Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker

R Fujita; Y Agid; P Trouillas; A Seck; C Tommasi-Davenas; A J Driesel; K Olek; K H Grzeschik; Y Nakamura; J L Mandel; A Hanauer

doi:10.1016/0888-7543(89)90323-6

Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker

Genomics. 1989 Jan;4(1):110-1. doi: 10.1016/0888-7543(89)90323-6.

Authors

R Fujita¹, Y Agid, P Trouillas, A Seck, C Tommasi-Davenas, A J Driesel, K Olek, K H Grzeschik, Y Nakamura, J L Mandel, A Hanauer

Affiliation

¹ U.184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.

PMID: 2563350
DOI: 10.1016/0888-7543(89)90323-6

Abstract

A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 9*
Deoxyribonucleases, Type II Site-Specific
Friedreich Ataxia / genetics*
Genetic Linkage
Genetic Markers
Humans
Interferon Type I / genetics
Polymorphism, Restriction Fragment Length

Substances

Genetic Markers
Interferon Type I
Deoxyribonucleases, Type II Site-Specific
TCGA-specific type II deoxyribonucleases