The off-target effects of nonspecific NK cells

Blood. 2015 Jan 29;125(5):744-5. doi: 10.1182/blood-2014-12-616359.

Abstract

In this issue of Blood, Shah et al describe the onset of severe acute graft-versus-host disease (GVHD) in 5 of 9 patients who received infusions of ex vivo expanded donor natural killer (NK) cells after HLA-matched hematopoietic stem cell transplantation (HSCT).

Publication types

  • Comment

MeSH terms

  • 4-1BB Ligand / pharmacology*
  • Female
  • Gastrointestinal Neoplasms / therapy*
  • Graft vs Host Disease / pathology*
  • Humans
  • Interleukin-15 / pharmacology*
  • Killer Cells, Natural / transplantation*
  • Male
  • Peripheral Blood Stem Cell Transplantation / methods*
  • Skin Neoplasms / therapy*

Substances

  • 4-1BB Ligand
  • IL15 protein, human
  • Interleukin-15